Uphill Battle of CRISPR/Cas9: A Budding Technology in Need of Refinement

Uphill Battle of CRISPR/Cas9: A Budding Technology in Need of Refinement

Gen Kaneko, Crystal Salinas, Hashimul Ehsan

Department of Biology, University of Houston-Victoria, 3007, N. Ben Wilson, Victoria, TX 77901

ABSTRACT: CRISPR/Cas9 has been a discovery that has developed advancements in the field of genetic engineering. This technology revolutionized genome editing by its ease of manipulation, high efficiency and broad range of applications within a number of hosts and a variety of diseases. Scientists have invested a lot of their attention in this system to reap the beneficial consequences of genome manipulation in animal cells. CRISPR has potential that we have yet to consider or uncover, but this is just the steppingstone to something far more than a system of genomic modification. It is still in its infancy, and thus far, there has been many developments since its discovery. To date, CRISPR/Cas9 requires refinement to hone its accuracy of delivery and safety. Its application to many different diseases, ranging from abnormal cell growth to neurodegenerative disorders, reveals an amalgamation of results, both positive and negative in outcome. This reveals the climate surrounding CRISPR/Cas9 progress.

KEYWORDS: CRISPR/Cas9, gene-editing technology, genomics, bioethics, media portrayal, regulations, enhancement, germline alterations