Garo Population of Bangladeshi Hilly Region Possesses Higher Frequency of ACE I/I Genotype in Angiotensin-converting Enzyme-1 (ACE-1) Gene

Abstract

A common polymorphism in the Angiotensin-converting Enzyme-1 (ACE-1) gene I/D variant have been shown to be associated in the context of physical performance. The present study was undertaken, to determine the frequency of ACE genotype polymorphism in Bengali, Garo and Rakhain populations of Bangladesh. A total of 338 healthy subjects were included in this study, among them 128 were Bengali, 96 were Garo and 114 were Rakhain. DNA was extracted and ACE I/D polymorphism was determined. Data were analyzed using SPSS for windows version 12. BMI of the Garo subjects was significantly lower than the Bengali and Rakhain subjects. Blood pressure of the Garo subjects was significantly higher than the Bengali subjects but lower than the Rakhain subjects. Serum triglyceride and total cholesterol of the Garo subjects were significantly lower than the Bengali subjects. Wild genotype (II) of ACE-1 gene in Garo subjects was significantly higher than the Bengali and Rakhain subjects. Variant genotype in hypertensive subjects of Bengali and Rakhain subjects were significantly higher. From the above results it can be concluded that Garo populations are associated with higher frequency of II genotype in ACE-1 gene and variant genotypes (II and ID) of ACE gene are associated with hypertension in Bengali and Rakhain subjects.