Correlation of serum alanine aminotransferase and hepatitis C viral RNA levels in Bangladeshi hepatitis patients

Authors

  • Mohammed Mohasin, TasninAkter Nila,Tahfima Sultana Tushy, KamrunNahar Keya and Md. Enamul Haque* Department of Biochemistry and Molecular Biology, University of Dhaka.

Keywords:

Hepatitis C virus, Alanine aminotransferase (ALT), Enzyme immunoassay (EIA), Nucleic acid amplification test (NAT)

Abstract

Hepatitis C virus (HCV) is the second largest
causative agent for liver infection (0.2-1% general population) in
Bangladesh. In hepatitis, both serum alanine aminotransferase
(ALT) and aspartate aminotransferase are elevated without showing
correlation of disease severity. However, serum ALT is the
commonest and reliable biochemical parameter for liver function
test. Hence, the correlation study of ALT and HCV RNA levels is
warranted to observe prospective treatment outcomes through
biochemical assay. OBJECTIVE: The investigation of serum ALT
and HCV RNA levels in acute and chronic hepatitis patients.
METHODS: Whole blood was collected from 112 patients. Serum
ALT levels were measured biochemically, serum antibody by EIA
and HCV-RNA was confirmed by NAT. RESULTS: Among the
enrolled hepatitis patients, there were comparable demographic
characteristics irrespective of their normal or elevated ALT levels.
Although 59% patients were HCV RNA undetectable, the higher
ALT levels were significantly correlated with HCV RNA positive
patients (p=0.0015). The latter patients group was mostly infected
with genotype 3 (67%) than genotype 1 (22%) and other genotypes
(11%). Conclusion: The confirmatory test and genotyping are
essential to determine the optimal duration of therapy.

 

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Published

2019-01-01

How to Cite

Mohammed Mohasin, TasninAkter Nila,Tahfima Sultana Tushy, KamrunNahar Keya and Md. Enamul Haque* (2019) “Correlation of serum alanine aminotransferase and hepatitis C viral RNA levels in Bangladeshi hepatitis patients”, Bioresearch Communications-(BRC). Dhaka, Bangladesh, 5(1), pp. 678-683. Available at: https://www.bioresearchcommunications.com/index.php/brc/article/view/153 (Accessed: 22May2022).

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Section

Original Article