Investigation of Potential Bioactive Compounds and Assessment of Anti-Diabetic Properties of Hydroclathrus Sp. Collected From the Bay of Bengal, Bangladesh
DOI:
https://doi.org/10.3329/brc.v11i1.78884Keywords:
Anti-diabetic, Hydroclathrus sp., Phytochemical Screening, In vivo, Alloxan, Alpha-AmylaseAbstract
Diabetes mellitus, a chronic metabolic disorder, has become a global health concern, prompting the exploration of alternative and sustainable sources for potential therapeutic agents. Seaweed extracts provide various benefits over synthetic medications, including lower toxicity and fewer side effects with diverse pharmacological properties, making them promising candidates for diabetes management. For this investigation, brown seaweeds, Hydroclathrus sp., were obtained from Saint Martin Island, Bangladesh. Following phytochemical analysis, the anti-diabetic efficacy of Hydroclathrus sp. was evaluated both in vitro and in vivo. In vitro studies showed that alpha-amylase inhibitory activity of 50% ethanolic extract of Hydroclathrus sp. was closely related to positive control acarbose. Besides, in vivo studies were conducted on alloxan-induced diabetes mice models, exploring the effects of Hydroclathrus sp. on blood glucose levels, and their biochemical profile was evaluated and found the algal extract at 100mg/kg body weight was more potent than the reference medicine (Glibinclamide) after 14 days of treatment. Lipid profiles and liver and kidney function tests also revealed the potent antidiabetic effects of 50% ethanolic extract of Hydroclathrus sp. These findings offer valuable information for the development of novel marine-derived anti-diabetic medications. However, further studies are required to elucidate and validate its true potential in diabetes.
References
Sarkar, M. S. I., Kamal, M., Hasan, M. M., Hossain, M. I., Shikha, F. H., and Rasul, M. G. (2017) Manufacture of different value added seaweed products and their acceptance to consumers. Asian Journal of Medical and Biological Research. 2, 639–645
Baweja, P., and Sahoo, D. (2015) Classification of Algae. 10.1007/978-94-017-7321-8_2
Michalak, I., and Chojnacka, K. (2018) Seaweeds As a Component of the Human Diet. Algae Biomass: Characteristics and Applications. 10.1007/978-3-319-74703-3_6
Islam, M. S., Sobuj, M. K. A., Islam, H. R., Hosain, M. E., and Rashid, M. H. (2023) Present status of Seaweed resources in Bangladesh: A review on the diversity, culture methods and utilization. Bangladesh Journal of Zoology. 50, 283–307
Rengasamy, K. R., Mahomoodally, M. F., Aumeeruddy, M. Z., Zengin, G., Xiao, J., and Kim, D. H. (2020) Bioactive compounds in seaweeds: An overview of their biological properties and safety. Food and Chemical Toxicology. 135, 111013
Pradhan, B., Bhuyan, P. P., Patra, S., Nayak, R., Behera, P. K., Behera, C., Behera, A. K., Ki, J. S., and Jena, M. (2022) Beneficial effects of seaweeds and seaweed-derived bioactive compounds: Current evidence and future prospective. Biocatalysis and Agricultural Biotechnology. 39, 102242
Cho, N., Kirigia, J., Ogurstova, K., and Reja, A. (2017) IDF Diabetes Atlas, tenth edition. [online] www.diabetesatlas.org (Accessed November 20, 2023)
Saeedi, P., Petersohn, I., Salpea, P., Malanda, B., Karuranga, S., Unwin, N., Colagiuri, S., Guariguata, L., Motala, A. A., Ogurtsova, K., Shaw, J. E., Bright, D., and Williams, R. (2019) Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: Results from the International Diabetes Federation Diabetes Atlas, 9th edition. Diabetes Research and Clinical Practice. 157, 107843
Borse, S. P., Chhipa, A. S., Sharma, V., Singh, D. P., and Nivsarkar, M. (2021) Management of Type 2 Diabetes: Current Strategies, Unfocussed Aspects, Challenges, and Alternatives. Medical Principles and Practice. 30, 109–121
Magkos, F., Hjorth, M. F., and Astrup, A. (2020) Diet and exercise in the prevention and treatment of type 2 diabetes mellitus. Nature Reviews Endocrinology. 16, 545–555
Khursheed, R., Singh, S. K., Wadhwa, S., Kapoor, B., Gulati, M., Kumar, R., Ramanunny, A. K., Awasthi, A., and Dua, K. (2019) Treatment strategies against diabetes: Success so far and challenges ahead. European Journal of Pharmacology. 862, 172625
Asif, M. (2014) The prevention and control the type-2 diabetes by changing lifestyle and dietary pattern. Journal of Education and Health Promotion. 3, 1
Padhi, S., Nayak, A. K., and Behera, A. (2020) Type II diabetes mellitus: a review on recent drug based therapeutics. Biomedicine & Pharmacotherapy. 131, 110708
Hippisley-Cox, J., and Coupland, C. (2016) Diabetes treatments and risk of amputation, blindness, severe kidney failure, hyperglycaemia, and hypoglycaemia: Open cohort study in primary care. BMJ (Online). 10.1136/bmj.i1450
Nwosu, F., Morris, J., Lund, V. A., Stewart, D., Ross, H. A., and McDougall, G. J. (2011) Anti-proliferative and potential anti-diabetic effects of phenolic-rich extracts from edible marine algae. Food Chemistry. 126, 1006–1012
Jung, H. A., Islam, M. N., Lee, C. M., Jeong, H. O., Chung, H. Y., Woo, H. C., and Choi, J. S. (2012) Promising antidiabetic potential of fucoxanthin isolated from the edible brown algae Eisenia bicyclis and Undaria pinnatifida. Fisheries Science. 78, 1321–1329
Sobuj, M. K. A., Rahman, S., and Ali, M. Z. (2024) A review on commercially important seaweed resources from the Bangladesh coast. Food Chemistry Advances. 4, 100655
Alzahrani, R. R., Alkhulaifi, M. M., and Al-Enazi, N. M. (2020) In vitro biological activity of Hydroclathrus clathratus and its use as an extracellular bioreductant for silver nanoparticle formation. Green Processing and Synthesis. 9, 415–427
Dahanayake, J. M., Perera, P. K., Galappatty, P., Perera, H. D. S. M., and Arawwawala, L. D. A. M. (2019) Comparative Phytochemical Analysis and Antioxidant Activities of Tamalakyadi Decoction with Its Modified Dosage Forms. Evidence-based Complementary and Alternative Medicine. 10.1155/2019/6037137
Richardson, P. M., and Harborne, J. B. (1990) Phytochemical Methods: A Guide to Modern Techniques of Plant Analysis. Second Edition., Chapman and Hall, 10.2307/2807624
Khoo, L. W., Audrey Kow, S., Lee, M. T., Tan, C. P., Shaari, K., Tham, C. L., and Abas, F. (2018) A Comprehensive Review on Phytochemistry and Pharmacological Activities of Clinacanthus nutans (Burm.f.) Lindau. Evidence-based Complementary and Alternative Medicine. 10.1155/2018/9276260
Gul, R., Jan, S. U., Faridullah, S., Sherani, S., and Jahan, N. (2017) Preliminary Phytochemical Screening, Quantitative Analysis of Alkaloids, and Antioxidant Activity of Crude Plant Extracts from Ephedra intermedia Indigenous to Balochistan. Scientific World Journal. 10.1155/2017/5873648
Rajeshkumar, R., and Jeyaprakash, K. (2016) Screening of UV-VIS, TLC and FTIR spectroscopic studies on selected red seaweed (Acanthophora specifera) collected from Gulf of Mannar. World Journal of Pharmaceutical Sciences. 4, 28–33
Mechchate, H., Es-Safi, I., Louba, A., Alqahtani, A. S., Nasr, F. A., Noman, O. M., Farooq, M., Alharbi, M. S., Alqahtani, A., Bari, A., Bekkari, H., and Bousta, D. (2021) In vitro alpha-amylase and alpha-glucosidase inhibitory activity and in vivo antidiabetic activity of withania frutescens l. Foliar extract. Molecules. 10.3390/molecules26020293
Gidado, A., Ameh, D. A., and Atawodi, S. E. (2005) Effect of Nauclea latifolia leaves aqueous extracts on blood glucose levels of normal and alloxan-induced diabetic rats. African Journal of Biotechnology. 4, 91–93
Siratantri, T., Yogabuana, M., and Olivia, S. (2014) An In Vitro Study of Antidiabetic Activity of Sargassum Duplicatum and Turbinaria Decurens Seaweed. International Journal of Pharmaceutical Science Invention ISSN (Online. 3, 2319–6718
Biochemical Analysis Techniques | Encyclopedia.com [online] https://www.encyclopedia.com/science/encyclopedias-almanacs-transcripts-and-maps/biochemical-analysis-techniques (Accessed December 8, 2023)
Tran, N., Pham, B., and Le, L. (2020) Bioactive compounds in anti-diabetic plants: From herbal medicine to modern drug discovery. Biology. 9, 1–31
Lenzen, S. (2008) The mechanisms of alloxan- and streptozotocin-induced diabetes. Diabetologia. 51, 216–226
Downloads
Published
How to Cite
Issue
Section
License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Author(s) will retain the copyright of their own articles. By submitting the article to Bioresearch Communications (BRC), the author(s) have granted the BRC for the use of the article.