Useful Effects of Omega-3 Fatty Acids on Serum Alkaline phosphatase And Gamma-glutamyl-transferase Levels in Middle Aged Patients with Diabetes mellitus

Abstract

Background: Patients with type-2 Diabetes are augmented the risk of non alchoholic fatty liver disease that rises liver enzymes. Dietary supplementation of omega-3 fatty acid may reduce liver enzymes. Objective: To observe the favourable effects of fish oil capsule on ALP and GGT in patients with type 2 DM. Methods: This prospective interventional study was conducted during 2017 in Physiology department DMC on 52 diagnosed type 2 diabetic patients of both sexes were scrutinized with age ranging from 40 to 50 years. Among them, 27 type 2 diabetic patients those who taken oral fish oil gel (2g/day) for 12 weeks were preferred as study group. Another 25 type 2 diabetic patients without any supplementation were nominated as control group for juxtra-position. The study subjects were scrutinized from Outdoor of Endocrinology Department, DMC, Dhaka and personal contact from Dhaka city on the basis of inclusion and exclusion criteria. The research work was administrated with ethical clearance from concerned authority. The study parameters serum ALP and GGT were estimated by enzymatic colorimetric method in auto-analyzer in Department of Laboratory Medicine, DMC, Dhaka. Serum TG and FBG also measured .The parameters were studied 2 times in study and control groups i.e. at the beginning of study (base line) and after 12 weeks of study period. Data were collected in pre-designed structured questionnaire from the researcher by herself. For statistical analysis, Paired Student’s ‘t’ test and Unpaired Student’s ‘t’ test were performed as applicable using SPSS for windows version 16.0. Results: In this study ALP (Alkaline- Phosphatase) and GGT(gamma[1]glutamyltransferase) were reduced in diabetic patients after supplementation with omega-3 fatty acid in comparison to that of their baseline value. Again, after 12 weeks, ALP(Alkaline Phosphatase) and GGT(gamma glutamyltransferase) were decreased in diabetic patients after supplementation with omega-3 fatty acid in comparison to control group. Conclusion: After analyzing the results of the study, it can be concluded that omega-3 fatty acid can reduce ALP and GGT levels in diabetic patients may be helpful to minimize the risk of fatty liver in type-2 diabetes mellitus.